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Vitamin Supplement Helps Defend Against Inflammatory Bowel Disorder

January 22, 2010: 07:46 AM EST
A vitamin widely found in supplements or cod liver oil, can counter the effects of the inflammatory bowel disorder Crohn's disease, Canadian scientists report. Vitamin D directly affects the Beta defensin 2 gene, which encodes an antimicrobial peptide, the NOD2 gene that alerts cells to the presence of invading microbes. Both Beta-defensin and NOD2 have been linked to Crohn's disease. If NOD2 is deficient or defective – for example, in sunlight-deprived people from northern countries – it cannot fight intestinal tract invaders. The researchers say their discovery “shows how an over-the-counter supplement … could help people defend themselves against Crohn's disease.”
Tian-Tian Wang, Basel Dabbas, et al., "Direct and indirect induction by 1,25-dihydroxyvitamin D3 of theNOD2/CARD15-beta defensin 2 innate immune pathway defective in Crohn's disease ", The Journal of Biological Chemistry, January 22, 2010, © American Society for Biochemistry and Molecular Biology
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