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Vitamin D Shows Promise As Treatment For Common Mold Allergy

August 16, 2010: 11:44 AM EST
Vitamin D may prove to be an effective treatment or preventive agent for a common mold allergy that often creates problems for asthmatics and cystic fibrosis (CF) patients. Aspergillus fumigatus, one of the most common environmental fungi inhaled by people, is usually not associated with disease. But asthmatics and CF patients often have severe allergic reactions. Researchers studied two groups of patients with CF. Both groups were colonized with A. Fumigatus, but only one group had the severe allergic response known as allergic bronchopulmonary aspergillosis (ABPA). Focusing on Th2 cells and a specific protein that play a major role in producing an allergic response, they discovered that increased Th2 reactivity, and thus allergic response, in the ABPA group correlated with lower blood levels of vitamin D.
James L. Kreindler, Chad Steele, et al., "Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis", Journal of Clinical Investigation, August 16, 2010, © The American Society for Clinical Investigation
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