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Turmeric Compound Shown Effective In Treating Damage From Ischemic Stroke

December 2, 2010: 02:41 PM EST

U.S. scientists working with a rabbit model of stroke found that a synthetic derivative of curcumin, the active ingredient in the curry spice turmeric, improved the behavioral and molecular deficits of ischemic stroke. The novel compound (CNB-001), researchers said, may have clinical promise for ischemic stroke, the third leading cause of death among older Americans. The only FDA-approved treatment for stroke is tissue plasminogen activator (TPA), which is effective only in about 20 percent of cases. Tests of the novel compound CNB-001 found it at least as effective as TPA in preventing the behavioral deficits caused by stroke. A separate study found that CNB-001 also dramatically reversed the behavioral deficits in locomotion and memory that accompany traumatic brain injury.

Paul A. Lapchak, et al., "Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke", Journal of Neurochemistry, December 02, 2010, © The authors
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