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Soy Chemical May Prevent Spread Of Cancer Cells Beyond The Prostate

November 8, 2010: 11:59 AM EST

U.S. researchers have developed a nontoxic drug from a natural chemical in soy that may prevent prostate cancer cells from migrating to the rest of the body, a process known as metastasization. The chemical genistein was tested in a randomized phase 2 study involving 38 men diagnosed with localized prostate cancer. Genistein given in pill form a month before prostate surgery “had beneficial effects” on the cancer cells. Studying the cancer cells after surgery, the researchers found that genistein increased the expression of genes that suppress the invasion of cancer cells and decreased the expression of genes that enhance invasion. The researchers hope to conduct a second phase 2 trial to determine if metastatic behavior is prevented.

Raymond Bergan, M.D., "Soy may stop prostate cancer spread", Presentation, AACR Frontiers in Cancer Prevention Research Conference, November 08, 2010, © Northwestern University
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