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Scientists Discover Why Antioxidants In Red Wine, Green Tea Retard Prostate Cancer

June 9, 2010: 03:41 PM EST
The antioxidants in red wine and green tea produce a combined effect that disrupts an important cell signaling pathway necessary for the growth of prostate cancer, French researchers have found. The discovery is important because the signaling pathway, known as SphK1/S1P, plays a role not only in prostate cancer, but also in colon cancer, breast cancer, and gastric cancers. Several different experiments were conducted, both in test tubes and in mouse models of prostate cancer. The mice treated with green tea and wine polyphenols showed reduced tumor growth because of the inhibited SphK1/S1P pathway. “These results provide the first demonstration that the SphK1/S1P pathway represents a target of dietary green tea and wine polyphenols in cancer,” the researchers concluded.
Leyre Brizuela, Audrey Dayon, et al., "The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.", The FASEB Journal, June 09, 2010, © Federation of American Societies for Experimental Biology
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