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Resveratrol Neutralizes Toxic Proteins Associated With Alzheimer’s Disease

May 28, 2010: 11:26 AM EST
Resveratrol, which has been shown to affect cancer and aging, has now been found to neutralize the toxic effects of proteins linked to Alzheimer’s disease, U.S. researchers reported. An organic compound found in red wine and grapes, resveratrol selectively targets and neutralizes certain toxic peptide isoforms, without affecting the benign ones. Peptide deformations have been linked to Alzheimer’s disease, in which improperly folded peptides collect to form “plaques” in the brain. The plaques are often found near areas of cell death in diseased brains. The intriguing finding in the research is that seemingly identical non-toxic and toxic arrangements have some yet undiscovered distinguishing feature, raising questions for future study. “It helps us to think about the structural differences between the peptide isoforms,” the researchers said.
Peter M. Tessier, et al., "Resveratrol selectively remodels soluble oligomers and fibrils of amyloid aß into off-pathway conformers", Journal of Biological Chemistry, May 28, 2010, © The American Society for Biochemistry and Molecular Biology
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