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July 8, 2010: 04:17 PM EST
U.S. researchers have found that six natural plant compounds – luteolin, quercetin, chrysin, eriodicytol, hesperetin, and naringenin – target an enzyme known as TBK1 that is associated with inflammation, which increases the risk of cancer, heart disease and diabetes. Each of the six compounds inhibits to some extent TBK1's ability to activate a specific biochemical signal that, if unimpeded, leads to formation of gene products known to trigger inflammation. The researchers found that luteolin, a known anti-inflammatory compound found in celery, thyme, green peppers, and chamomile tea, was the most effective inhibitor of TBK1. Foods rich in quercetin include capers, apples, and onions. Chrysin is from the fruit of blue passionflower. Oranges and other citrus fruits are good sources of eriodicytol, hesperetin, and naringenin.
Daniel H. Hwang, "Cancer-Fighting Roles of Intriguing Plant Compounds", Agricultural Research, July 08, 2010, © Agricultural Research Service (USDA)
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