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Phosphates May Play Role In Mammalian Aging Process - Study

April 23, 2010: 10:23 PM EST
Research involving genetically engineered mice by Japanese and American scientists suggests that phosphate levels in the mammalian body may play a role play in the aging process. Phosphates are chemicals that add a tangy taste to carbonated beverages. The scientists tested the effect of genetically removing a phosphate transporter in the kidneys of mice engineered to age prematurely. With reduced phosphate levels in their bodies, the mice showed no signs of premature aging: they remained fertile, for example, and showed less skeletal and muscle wasting. When the mice were subsequently fed a high-phosphate diet, they began to show symptoms of aging. The researchers concluded that their “dietary and genetic manipulation” showed that phosphate toxicity accelerated the aging process in the mice. The researchers did not, however, blame aging in humans on phosphate consumption.
Mutsuko Ohnishi and M. Shawkat Razzaque , "Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging ", The FASEB Journal, April 23, 2010, © The Federation of American Societies for Experimental Biology.
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