High-Fat Diet Induces Body Fat Increases That Stay From Generation To Generation

August 1, 2010: 04:34 AM EST

A French study in mice has found that eating a high-fat Western-style diet rich in linoleic acid and low in alpha-linolenic acid tends to increase body fat from generation to generation. In the study, male and female mice were fed a high-fat diet (35% energy as fat), then mated randomly and maintained on the same diet for successive generations. Researchers found that offspring over four generations showed a gradual increase in body fat “due to combined hyperplasia (tissue enlargement) and hypertrophy (cell enlargement) with no change in food intake.” The researchers concluded that, without diet changes over successive generations, “a Western-like fat diet induces a gradual fat mass enhancement, in accordance with the increasing prevalence of obesity observed in humans.”

Florence Massiera, Pascal Barbry, Philippe Guesnet, Aurélie Joly, Serge Luquet, Chimène Moreilhon-Brest, Tala Mohsen-Kanson, Ez-Zoubir Amri and Gérard Ailhaud, "A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations", J. Lipid Research, August 01, 2010, © American Society for Biochemistry and Molecular Biology

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High-Fat Diet Induces Body Fat Increases That Stay From Generation To Generation

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