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Greater Effort Needed To Advise Patients Of Side Effects Of NSAIDs

June 17, 2010: 12:27 PM EST
Only forty percent of patients at high risk of gastrointestinal side effects from nonsteroidal anti-inflammatory drugs (NSAIDs) were advised about ways to prevent problems, but the rest were not, a new study from The Netherlands has found. Researchers examined health records from 1996 to 2006 of 50,126 NSAID users aged 50 or over. The number of patients receiving preventative strategies did increase five-fold during that time, but the researchers stressed that greater efforts need to be made to advise patients at high risk of side effects, which can range from mild indigestion to bleeding, perforation or obstructions that can lead to hospitalization and even death. Side effects can be prevented by using a COX inhibitor NSAID instead of a nonselective NSAID and combining NSAIDs with gastroprotective agents, the researchers said.
Valkhoff et al. , "Time-trends in gastroprotection with nonsteroidal anti-inflammatory drugs (NSAIDS)", Alimentary Pharmacology & Therapeutics, June 17, 2010, © Blackwell Publishing Ltd.
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