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Binge Drinking Causes Long-Term Disruption Of Genes Involved In Bone Formation

July 9, 2010: 01:12 PM EST
A U.S. study has found long-lasting disruptions in hundreds of genes involved in bone formation in rats that were injected with large amounts of alcohol. According to the researchers, the findings should serve as a warning to teenagers about the long-term effects of binge drinking on bone development, including an increased risk of fractures and osteoporosis. Binge drinking is defined as a woman having at least four drinks or a man having at least five drinks on one occasion. In the study, rats received injections of alcohol that resulted in a blood alcohol level of 0.28. Researchers found long-lasting disruption of about 300 bone-related genes in rats exposed to acute binge drinking and about 180 bone-related genes in rats exposed to chronic binge drinking.
John Callaci, Ph.D., Kristen Lauing and Phillip Roper, "Long-Term Modulations in the Vertebral Transcriptome of Adolescent-Stage Rats Exposed to Binge Alcohol", Alcohol and Alcoholism, July 09, 2010, © Medical Council on Alcohol
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